Long-Term Melatonin Use Linked to Increased Heart Failure Risk
A recent study presented at the American Heart Association (AHA) Scientific Sessions 2025 highlights significant risks associated with prolonged melatonin use in adults suffering from insomnia.
Study Findings
Researchers analyzed health data from over 130,000 adults with insomnia and no prior heart failure history. Those who used melatonin for at least one year were found to have a roughly 90% higher likelihood of developing heart failure within five years compared to non-users. Additionally, long-term users showed a markedly increased risk of hospitalization or death during the same period.
Risk Comparison
- Long-term melatonin users had an 82% higher heart failure risk in the UK when prescribed melatonin twice, 90 days apart.
- They were about 3.5 times more likely to be hospitalized for heart failure than those who did not use melatonin.
Context and Usage
Melatonin is a popular over-the-counter supplement in the United States, used by nearly six million people to improve sleep onset and duration. However, this study suggests caution for adults with insomnia considering long-term melatonin use.
"Adults with insomnia who took melatonin for at least a year had a much higher chance of developing heart failure," stated the researchers.
The findings urge medical professionals and patients to weigh the benefits and potential heart-related risks before committing to extended melatonin supplementation.
Author's Summary
Long-term melatonin use in adults with insomnia is associated with a significantly increased risk of heart failure, hospitalization, and mortality, suggesting careful consideration is needed before prolonged use.
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