New study links melatonin and heart failure, but experts say don’t panic yet

New Study Links Melatonin and Heart Failure

A recent study analyzing health records of tens of thousands of adults with chronic insomnia found a connection between long-term melatonin use and an increased risk of heart failure. According to the American Heart Association, individuals who took prescribed melatonin for over a year had a higher likelihood of developing heart failure within five years compared to nonusers.

The study also indicated that melatonin users were more frequently hospitalized for heart failure and had a higher all-cause mortality rate than those who did not use the supplement.

Expert Reactions and Cautions

Despite these findings, sleep medicine specialists and cardiologists have responded with caution. They emphasize that the study has not yet undergone peer review and urge the public not to make sudden changes based on these preliminary results.

Experts stress the need for further research into the long-term use of melatonin, as current evidence on its effects, including potential benefits for heart failure patients, remains mixed.

Context of the Study

The preliminary data was shared in a research abstract scheduled for presentation at the American Heart Association’s Scientific Sessions, a prominent conference focusing on cardiovascular science and medicine.

"The researchers behind the study also reported that people taking melatonin were more likely to be hospitalized for heart failure and die of any cause than those who did not use the supplement."
"The preliminary results, which appear to contradict existing research suggesting that melatonin might have health benefits for people with heart failure, are from a research abstract that is expected to be presented at the American Heart Association’s Scientific Sessions."
Additional Information

Author’s summary: Early findings link long-term melatonin use to increased heart failure risk, but experts advise caution and call for more thorough studies before drawing conclusions.

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Toronto Sun Toronto Sun — 2025-11-07