Long-Term Melatonin Use May Increase Heart Risks
New research suggests that taking melatonin supplements for extended periods to address sleep problems might pose unexpected hazards to heart health. Chronic melatonin users were found to have nearly double the risk of death and were 3.5 times more likely to be hospitalized due to heart failure.
Study Highlights
A preliminary study presented at the American Heart Association's Scientific Sessions 2025 revealed that adults with chronic insomnia who used melatonin for a year or more experienced higher chances of developing heart failure, hospitalization from it, and increased mortality from any cause compared to non-users.
The AHA's annual meeting, held from November 7-10 in New Orleans, provided a platform for discussing these findings, which are significant for cardiovascular science and clinical research.
What Is Melatonin?
Melatonin is a hormone naturally produced by the pineal gland, controlling the body's sleep-wake cycle by rising in darkness and falling in daylight. Synthetic melatonin, identical to the natural hormone, is commonly used to treat insomnia and jet lag.
In the United States and many other countries, melatonin supplements are available over the counter. However, due to a lack of strict regulation in the U.S., the purity and dosage of these products can vary considerably.
"Adults with chronic insomnia who used melatonin for a year or longer were more likely to develop heart failure, be hospitalized for heart failure, and die from any cause than those who did not take the supplement."
Experts now advise caution with long-term melatonin use despite its general reputation as a safe remedy for sleep issues.
Author's Summary
While melatonin is often seen as a safe sleep aid, new research links prolonged use to serious cardiovascular risks, highlighting the need for careful consideration before long-term use.