NFL picks, predictions: 3 plus-money bets for Week 6

NFL Picks and Predictions for Week 6

autor's summary: 3 plus-money bets for Week 6.

The NFL is back with a highly-anticipated slate of games in Week 6, and here are 3 plus-money bets to consider before kickoff.

By Spenser Davis, Published: Oct 12, 2025 · 8:30 AM EDT. It’s time for Week 6 of the NFL season, and we’ll explore some plus-money NFL picks.

Last week, our NFL bold predictions went 2-1 and came out +1.17 units overall. Since the start of Week 3, picks in this story are up 2.16 units.

3 Bold Predictions for Week 6

Fading the Colts offense may not be the wisest choice, but there is a case for doing so. Indianapolis is currently averaging 3.39 points per drive, which would be the most this century if the Colts maintain this pace all season long.

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